Combined Blockade of VEGFR-3 and VLA-1 Markedly Promotes High-Risk Corneal Transplant Survival
Identifieur interne : 004F94 ( Main/Exploration ); précédent : 004F93; suivant : 004F95Combined Blockade of VEGFR-3 and VLA-1 Markedly Promotes High-Risk Corneal Transplant Survival
Auteurs : Hui Zhang ; Sammy Grimaldo ; Don Yuen ; Lu ChenSource :
- Investigative Ophthalmology & Visual Science [ 0146-0404 ] ; 2011.
Abstract
The authors provide the first evidence that a combined blockade of VEGFR-3 and VLA-1 promotes 90% survival of high-risk corneal transplants. Moreover, a strong correlation is revealed between high-risk transplant rejection and high degree of lymphangiogenesis reaching the donor-graft border.
Url:
DOI: 10.1167/iovs.11-7454
PubMed: 21715348
PubMed Central: 3176031
Affiliations:
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sort="Yuen, Don" uniqKey="Yuen D" first="Don" last="Yuen">Don Yuen</name><affiliation><nlm:aff id="aff1">From the Center for Eye Disease and Development, Program in Vision Science and School of Optometry, University of California, Berkeley, California.</nlm:aff><wicri:noCountry code="subfield">California.</wicri:noCountry></affiliation></author><author><name sortKey="Chen, Lu" sort="Chen, Lu" uniqKey="Chen L" first="Lu" last="Chen">Lu Chen</name><affiliation><nlm:aff id="aff1">From the Center for Eye Disease and Development, Program in Vision Science and School of Optometry, University of California, Berkeley, California.</nlm:aff><wicri:noCountry code="subfield">California.</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21715348</idno><idno type="pmc">3176031</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176031</idno><idno type="RBID">PMC:3176031</idno><idno 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VLA-1 Markedly Promotes High-Risk Corneal Transplant Survival</title><author><name sortKey="Zhang, Hui" sort="Zhang, Hui" uniqKey="Zhang H" first="Hui" last="Zhang">Hui Zhang</name><affiliation><nlm:aff id="aff1">From the Center for Eye Disease and Development, Program in Vision Science and School of Optometry, University of California, Berkeley, California.</nlm:aff><wicri:noCountry code="subfield">California.</wicri:noCountry></affiliation></author><author><name sortKey="Grimaldo, Sammy" sort="Grimaldo, Sammy" uniqKey="Grimaldo S" first="Sammy" last="Grimaldo">Sammy Grimaldo</name><affiliation><nlm:aff id="aff1">From the Center for Eye Disease and Development, Program in Vision Science and School of Optometry, University of California, Berkeley, California.</nlm:aff><wicri:noCountry code="subfield">California.</wicri:noCountry></affiliation></author><author><name sortKey="Yuen, Don" sort="Yuen, Don" uniqKey="Yuen D" first="Don" last="Yuen">Don Yuen</name><affiliation><nlm:aff id="aff1">From the Center for Eye Disease and Development, Program in Vision Science and School of Optometry, University of California, Berkeley, California.</nlm:aff><wicri:noCountry code="subfield">California.</wicri:noCountry></affiliation></author><author><name sortKey="Chen, Lu" sort="Chen, Lu" uniqKey="Chen L" first="Lu" last="Chen">Lu Chen</name><affiliation><nlm:aff id="aff1">From the Center for Eye Disease and Development, Program in Vision Science and School of Optometry, University of California, Berkeley, California.</nlm:aff><wicri:noCountry code="subfield">California.</wicri:noCountry></affiliation></author></analytic><series><title level="j">Investigative Ophthalmology & Visual Science</title><idno type="ISSN">0146-0404</idno><idno type="eISSN">1552-5783</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The authors provide the first evidence that a combined blockade of VEGFR-3 and VLA-1 promotes 90% survival of high-risk corneal transplants. Moreover, a strong correlation is revealed between high-risk transplant rejection and high degree of lymphangiogenesis reaching the donor-graft border.</p></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Chen, Lu" sort="Chen, Lu" uniqKey="Chen L" first="Lu" last="Chen">Lu Chen</name><name sortKey="Grimaldo, Sammy" sort="Grimaldo, Sammy" uniqKey="Grimaldo S" first="Sammy" last="Grimaldo">Sammy Grimaldo</name><name sortKey="Yuen, Don" sort="Yuen, Don" uniqKey="Yuen D" first="Don" last="Yuen">Don Yuen</name><name sortKey="Zhang, Hui" sort="Zhang, Hui" uniqKey="Zhang H" first="Hui" last="Zhang">Hui Zhang</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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